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公司成立以来,先后承担国家“重大新药创制”4项、“863计划”2项、“十一•五国家科技支撑计划”2项、“国家发改委高技术产业化专项”1项等近80项政府课题。

 

文献

1. Ye, G., Wu, H., Huang, J., Wang, W., Ge, K., Li, G.& Huang, Q. (2020). LAMP2: a major update of the database linking antimicrobial peptides.Database,2020:baa061. 

 

2. 唐立成,吴宏宇,黄青山. CHAP 抗生酶数据库的构建及其信息分析. 中国抗生素杂志,44(8):904-909.

 

 

3. Hongyu Wu, Jinjiang Huang, Yang Zhong, Qingshan Huang. DrugSig: A resource for computational drug repositioning utilizing gene expression signatures. 2017, 12(5):e0177743.

 

4. Yuqiang Xu, Kuikui Ge, Junhao Lu, Jinjiang Huang, Wei Wei, Qingshan Huang. MicroRNA-493 suppresses hepatocellular carcinoma tumorigenesis through down-regulation of anthrax toxin receptor 1 (ANTXR1) and R-Spondin 2 (RSPO2). Biomedicine & Pharmacotherapy,93(2017):334-343.

5. Kuikui Ge,, Jinjiang Huang,, Wei Wang, Meigang Gu, Xinchuan Dai, Yuqiang Xu, Hongyu Wu, Guodong Li, Hairong Lu, Jiang Zhong, Qingshan Huang. Serine protease inhibitor kazal-type 6 inhibits tumorigenesis of human hepatocellular carcinoma cells via its extracellular action. Oncotarget,  2017,8(4):5965-5975.

6. 许燕,张宜涛,叶贵子,陆海荣,黄青山.重组溶葡萄球菌酶成品蛋白含量测定方法的建立. 生物技术通报, 2016,32(7):54-58.

 

 

7. 陆珉,黄青山,张继恩.重组溶葡萄球菌酶阴道泡腾片的质量研究.中国兽药杂志,2015,49(12):14-19.

 

 

8. 戴薪传,俞一鸣,葛葵葵,黄青山.腺病毒介导的SPINK6表达在肝癌细胞QGY-7703中功能的初步研究. 复旦学报(自然科学版), 2015,54(1):35-41.

 

9. 钱雯琼,葛葵葵,黄晋江,黄青山. SPINK6蛋白在人乳腺癌细胞MCF-7中的表达与定位研究. 复旦学报(自然科学版), 2015,54(1):28-34.

 

10韦唯,葛葵葵,徐宇强,黄晋江,黄青山. MicroRNA-493抑制乳腺癌MCF7细胞增殖、迁移和成瘤能力. 中国细胞生物学学报, 2015,37(4)486-492.

 

11. 王克强,吴宏宇,李国栋,黄青山. BCTD:一个药物重定位研究用药物靶点数据. 计算生物学, 2015,5(3):41-47.

 

 

12. 陆海荣,张宜涛,黄青山.重组溶葡萄球菌酶的PEG定点修饰.生物工程学报,2015,31(12)1-8.

 

 

13. Bai Xue, Cheng Zhang, Yihan Wang, Jincheng Wang, Jien Zhang,Min Lu, Guodong Li, Zhizhong Cao, Qingshan Huang.A Novel Controlled-Release System for Antibacterial Enzyme Lysostaphin Delivery Using Hydroxyapatite/Chitosan Composite Bone Cement. PLOS ONE,2014, 9(12): e113797.

14. Hongyu Wu , Jinjiang Huang, Hairong Lu,Guodong Li,Qingshan Huang. GMEnzy: A Genetically Modified Enzybiotic Database. PLOS ONE,2014, 9(8): e103687.

 

15. Wang Jin-cheng, Xue Bai, Ge Kui-kui, Wang Yi-han, Li Guo-dong, Huang Qingshan. Controlled release by novel lysostaphin-loaded hydroxyapatite/chitosan composites. 药学学报,2014,49(9):1331-1339

 

16. 叶贵子,张幼定,陆珉,等. 重组溶葡萄球菌酶泡腾栓在母猪体内的药动学与阴道内残留消除研究[J].中国猪业,2013,81(3):56-58.

 

 

17. 陆珉,钱春妹,张鲁敬,等.重组溶葡萄球菌酶粉的抑杀菌效果试验[J]. 中国乳业,2013,135(3):30-32.

 

 

18. 解虹,张鲁敬,钱春妹,等.非最终灭菌无菌灌装生产工艺人员微生物质量风险分析[J].中国兽药杂志,2013,47(7):18-21.

 

 

19. Xiaowei Zhao,Hongyu Wu,Hairong Lu,Guodong Li,Qingshan Huang. A Database Linking Antimicrobial Peptides. PLOS ONE, 2013, 8(6): e66557.

 

20. Hai-Rong Lu, Mei-Gang Gu, Qiang Huang, Jin-Jiang Huang, Wan-Ying Lu, Hong Lu, Qing-Shan Huang. H/D Exchange Mass Spectrometry and Site-Directed Cross-Linking Suggest an Important Dynamic Interface between the Two lysostaphin Domains. Antimicrobial Agents and Chemotherapy,2013,57(4):1872-1881.

21. 徐晓敏,张幼定,叶贵子,等.宫溯康预防奶牛产后子宫内膜炎的临床试验[J].中国乳业,2012,126(6):48-50.

 

 

22. 马怀彦,陈华鹏,徐国兴,等.复合溶菌酶粉剂防治犬腹泻的效果观察[J].宠物兽医,2012,(1):55-58.

 

 

23. 陆锦春,陈华鹏,马怀彦,张继恩,江海洋,史为民,沈建忠,黄青山.重组溶葡萄球菌酶在患子宫内膜炎奶牛体内的药代动力学与残留研究.中国乳业,2012,2:40-44.

 

24. Cheng Zhang,Guodong Li,Yihan Wang,Fuying Cui,Jien Zhang,Qingshan Huang. Preparation and characterization of 5-fluorouracil-loaded PLLA-PEG/PEG nanoparticles by a novel supercritical CO2 technique. International Journal of Pharmaceutics.2012,436(1-2):272-281.

25. Hongyu Wu,Hairong Lu,Jinjiang Huang,Guodong Li,Qingshan Huang. EnzyBase: a novel database for enzybiotic studies. BMC Microbiology 2012, 12:54.

 

26. 张赪,崔福英,李国栋,汪益涵,蒋司嘉,杨武利,李国栋,黄青山,载5-氟尿嘧啶纳米微球治疗荷H22腹水瘤小鼠的实验研究,中华临床医师杂志,2012,6(11):6-11.

 

27. H.R. Lu, J.J. Huang, G.D. Li, K.K. Ge, H.Y. Wu, Q.S. Huang, Expression, purification and characterization of recombinant human serine proteinase inhibitor Kazal-type 6 (SPINK6) in Pichia pastoris, Protein Expr. Purif.2012,82:144-149.

 

28. HUANG Jin-jiang, LU Jin-chun, LU Min, HUANG Qing-shan, LI Guo-dong. The design and construction of K11:a novel α-helical antimicrobial peptide. International Journal of Microbiology. 2012:764834.

 

29. 杨菲菲,莫云杰,李国栋,黄青山.重组溶葡萄球菌酶在烧伤患者的人体药代动力学,中国新药杂志,2012,21(16):1864-1866,1877.

 

30. 蒋司嘉,张继恩,吴聪明,李国栋,左之才,沈建忠,黄青山. 重组溶葡萄球菌酶对奶牛乳房炎的疗效研究.中国兽药杂志,2011,45(12):23~

 

 

31. 陆敏,许黎明,吴宏宇,李国栋,黄青山.重组溶葡萄球菌酶在牛奶中的性质研究.生物技术通报,2011,5:162-166.

 

 

32. Fuying Cui, Guodong Li, Jinjiang Huang, Jien Zhang, Min Lu, Wanying Lu, Jingning Huan and Qingshan Huang. Development of Chitosan-Collagen Hydrogel Incorporated with Lysostaphin (CCHL) burn dressing with Anti-Methicillin-Resistant Staphylococcus aureus and Promotion wound healing properties. Drug Delivery, 2011 Apr;18(3):173-80. 

33. Fuying Cui, Guodong Li, Jinjiang Huang , Jien Zhang, Min Lu,Wanying Lu, and Qingshan Huang. Extension of nasal anti-Staphylococcus aureus efficacy of lysostaphin by its incorporation into a chitosan-o/w cream.  Drug Delivery, 2010 Nov;17(8):617-23.

 

34. 陆海荣,黄晋江,李斌宾,吴宏宇,陆敏,黄青山. 肺炎球菌噬菌体裂解酶CPL-1的克隆表达、纯化和抑菌活性研究.中国感染与化疗杂志: 2010(02) :139-142. 

 


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